Clinical from the U.S. National Institutes of Health

Cochrane Central Register of Controlled Trials (CCRCT) CCRCT (also called CENTRAL) is the Cochrane Collaboration's register of reports of studies that may be relevant for inclusion in Cochrane [Systematic] Reviews. CENTRAL aims to include all relevant reports that have been identified through the work of The Cochrane Collaboration, through the transfer of this information to the US Cochrane Center. It is one of the databases that comprise The Cochrane Library and is currently licensed through EBSCO.

European Union Clinical Trials Register the European Medicines Agency’s European Clinical Trials Register
From January 1, 2015 forward, the EMA will publish all clinical reports contained in drug applications submitted to the agency. Reports will be published as soon as a decision is published on an application.

International Clinical Trials Registry Platform Search Portal maintained by the World Health Organization (WHO)
Includes data imported:
Every week from:
  • Australian New Zealand Clinical Trials Registry
  • EU Clinical Trials Register (EU-CTR)
  • International Standard Randomised Controlled Trial Number Register (ISRCTN)
Every 4 weeks from:
  • Brazilian Clinical Trials Registry (ReBec)
  • Chinese Clinical Trial Registry
  • Clinical Trials Registry - India
  • Clinical Research Information Service - Republic of Korea
  • Cuban Public Registry of Clinical Trials
  • German Clinical Trials Register
  • Iranian Registry of Clinical Trials
  • Japan Primary Registries Network
  • Pan African Clinical Trial Registry
  • Sri Lanka Clinical Trials Registry
  • The Netherlands National Trial Register
  • Thai Clinical Trials Register (TCTR)

Access to Janssen Clinical Trial Data for Janssen, the pharmaceutical company of Johnson & Johnson.

Clinical Study Data Portal for clinical trial data from participating pharmaceutical companies (Click on the links, for inclusion criteria for each company):
  • Astellas (Phase 1-4 studies, completed after Jan. 2010 on products and indications approved in the US and/or EU.)
  • Bayer (January 2014-present)
  • Boehringer Ingelheim (January 1998-present)
  • Glaxo Smith Kline (January 2007-present)
  • Lilly (Phase 2, 3, or 4 studies submitted on or after 1999, or with a first patient visit after Jan 1, 2014. Additional studies outside of this scope may be proactively listed by Lilly.)
  • Novartis (January 2014-present; phase 2 & 3 trials only)
  • Roche (January 1999-present)
  • Sanofi (January 2014-present)
  • Takeda (January 1, 2005-present)
  • UCB (Includes clinical studies that were considered pivotal for regulatory approval of cerolizumab pegol, cacosamide, rotigotine and levetiracetam. Requests for access to additional clinical study data will be considered on a case-by-case basis.)
  • Viiv Healthcare

SynRG Orange Papers summarize Russian clinical trial research on a quarterly basis, in English & Russian, from 2006 to the present, and are published by Synergy Research Group, a Russian contract research organization.

Yale University Open Data Access Project (YODA) from the Yale School of Medicine Center for Outcomes Research & Evaluation (CORE). Trials conducted by Johnson & Johnson and Medtronic, Inc are searchable.

Additional references AllTrials is an initiative of Bad Science, the British Medical Journal, the Centre for Evidence-based Medicine, Cochrane Collaboration, James Lind Initiative, PLOS, and Sense About Science and, in the United States, Dartmouth University’s Geisel School of Medicine and the Dartmouth Institute for Health Policy & Clinical Practice.

Bergström, Richard.The Journey of Clinical Trials. EFPIA. 2013.

Doshi P, Jefferson T, Del Mar C. The Imperative to Share Clinical Study Reports: Recommendations from the Tamiflu Experience. PLoS Med. 2012;9(4):e1001201. doi:10.1371/journal.pmed.1001201.

FDA’s Guidance for Industry: Structure and Content of Clinical Study Reports. 1996.

FDA’s Guidance for Industry: Structure and Content of Clinical Study Reports Questions and Answers. 2013.

Goldacre B. What doctors don’t know about the drugs they prescribe. TEDMED 2012; 2012.

Institute of Medicine. Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk; 2015.

Jones N. Half of US clinical trials go unpublished. Nature. 2013. doi:10.1038/nature.2013.14286.

Pharmaceutical Research and Manufacturers of America (PhRMA). Principles for Responsible Clinical Trial Data Sharing. 2013.

Wieseler B, Wolfram N, McGauran N, et al. Completeness of Reporting of Patient-Relevant Clinical Trial Outcomes: Comparison of Unpublished Clinical Study Reports with Publicly Available Data. PLoS Med. 2013;10(10):e1001526. doi:10.1371/journal.pmed.1001526.

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phone: (276) 498-5239

Rev. 11/16